The skin is composed of the epidermis and dermis, and the dermis is divided into two major layers.
The top layer and the lower layer, both of these layers contain collagen and elastin. The collagen is in the lower layer of the dermis while the elastin is in the upper layer of the dermis.
Whatever the cause of sun or free radicals within the skin, the elastin undergoes degradation from enzyme Elastase. The specific action of elastase is to break down elastic fibers. The result is a loss of retraction in the skins, the skin is pulled by gravity, so that the skin droops and stays droopy.
Elastin of skin (laxity)
Skin laxity is one major sign in aging seen before wrinkles, because of contrasted with sun-damaged.
Usually there is a noticeable discoloration of the skin before other changes are seen, and the skin reddish-brown, almost leather- like appearance. Real wrinkles starting first around the eyes and mouth, progressing to the middle and lower face and then the neck.
As the process continues, the wrinkles become deeper. If the individual is a smoker and drinker, besides being a sunbather, the progress is very fast after the 37-40 age range.
‘Age”, “Sex,”
Autoimmune diseases can occur at any age, a general tendency exists for autoimmune disease to become more common with increasing age. Sex is another thing, women are more likely to develop many of the autoimmune disorders, with more different probabilities for different disorders. Overall autoimmune disease are five times more common in women than in men.
What is the difference between Collagen and Elastin
The connective tissue consists of three type of fibers, Collagen, Elastin and Reticulum. Collagenis composed of complex fibers made up of protein and arranged in long chains. Collagen is tough anddoes not strech easily and makes up 10 to 30% of the wet weight of the dermis. Elastin is composed of a highly resilient material that chemically is different from collagen